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The University of South Carolina Upstate is a separately-accredited, public comprehensive university within the USC System. True to its mission, USC Upstate is developing the next generation of globally competitive workers in the state by providing an accessible, rigorous, career-relevant education that meets the needs of both students and industry. The university is a major engine of social, economic, and talent development, with an annual economic impact of more than half a billion dollars.

USC Upstate is located in Spartanburg, in the foothills of the Blue Ridge Mountains, between Atlanta, GA and Charlotte, NC. Among the fastest-growing, baccalaureate-granting institutions in the nation, USC Upstate is recognized by U.S. News & World Report as #2 among Southern Regional Public Colleges. As a member of the Big South Conference, USC Upstate Spartans compete in 17 NCAA Division I sports.

Home to more than 6,150 students, USC Upstate offers more than 40 undergraduate and graduate programs within five distinctive colleges and schools. The Mary Black School of Nursing features a state-of-the-art simulation lab that represents the largest solely dedicated to nursing in the state. The George Dean Johnson, Jr. College of Business and Economics is among just 15 percent of business schools worldwide to be accredited by AACSB International, and the School of Education, Human Performance, and Health employs an interdisciplinary approach that underscores the importance of developing educators who understand the intersections of education and community health. The School is accredited by CAEP, the Council for the Accreditation of Educator Preparation.

In 2018, USC Upstate created two new colleges from the College of Arts and Sciences. The College of Science and Technology aims to meet the talent needs of enterprises focused on Science, Technology, Engineering and Math (STEM), including in-demand careers in life sciences, advanced manufacturing, and advanced materials. The College of Arts, Humanities, and Social Sciences, centers on creativity and innovation, builds upon a strong foundation and dedicates itself to promoting the significance of the liberal and fine arts as well as the social and behavioral sciences.

USC Upstate is uniquely positioned to create transformative opportunities through higher education to better serve the needs of the region, fulfilling critical workforce needs while contributing to the social, cultural and economic development of the Upstate of South Carolina. More than 30,000 students have earned their degrees from USC Upstate, and nearly 85 percent of those alumni choose to remain in the Upstate to build their lives and careers.